Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia
Identifieur interne : 000388 ( Main/Exploration ); précédent : 000387; suivant : 000389Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia
Auteurs : Yuanyuan Liu ; Hong Song ; Huanqing Song ; Xiaoxia Feng ; Chuan Zhou ; Zhifang HuoSource :
- AMB Express [ 2191-0855 ] ; 2019.
Abstract
Due to its potent cytotoxicity in BRCA-mutated tumors, synthetic lethality elicited by poly (ADP-ribose) polymerase (PARP) inhibitor gives renewed enthusiasm to researching and developing anti-cancer therapies. Chronic myeloid leukemia (CML) is a type of cancers that starts in certain blood-forming cells of the bone marrow. Here, we showed that poly (ADP-ribose) polymerase (PARP) inhibitor talazoparib could induce a concentration-dependent cytotoxicity in CML cells derived from pediatric patients. During talazoparib treatment, autophagy was markedly activated, which was confirmed by the accumulation of autophagosomes, decrease of SQSTM1 and up-regulation of LC3-II. Inhibition of autophagy by pharmaceutical inhibitor chloroquine or small-interfering RNA siATG5 significantly increased the cytotoxicity of talazoparib in pediatric CML cells and elicited synergistic anti-tumor effect in patient-derived xenograft model. Our data demonstrated that autophagy played a cyto-protective role in talazoparib-treated pediatric CML and co-treatment with talazoparib and autophagy inhibitor could induce synergetic anti-tumor effect, providing novel insights for pediatric CML treatment.
Url:
DOI: 10.1186/s13568-019-0836-z
PubMed: 31309361
PubMed Central: 6629728
Affiliations:
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Chronic myeloid leukemia (CML) is a type of cancers that starts in certain blood-forming cells of the bone marrow. Here, we showed that poly (ADP-ribose) polymerase (PARP) inhibitor talazoparib could induce a concentration-dependent cytotoxicity in CML cells derived from pediatric patients. During talazoparib treatment, autophagy was markedly activated, which was confirmed by the accumulation of autophagosomes, decrease of SQSTM1 and up-regulation of LC3-II. Inhibition of autophagy by pharmaceutical inhibitor chloroquine or small-interfering RNA siATG5 significantly increased the cytotoxicity of talazoparib in pediatric CML cells and elicited synergistic anti-tumor effect in patient-derived xenograft model. Our data demonstrated that autophagy played a cyto-protective role in talazoparib-treated pediatric CML and co-treatment with talazoparib and autophagy inhibitor could induce synergetic anti-tumor effect, providing novel insights for pediatric CML treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashworth, A" uniqKey="Ashworth A">A Ashworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Ye, L" uniqKey="Ye L">L Ye</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Liao, S" uniqKey="Liao S">S Liao</name></author><author><name sortKey="Song, P" uniqKey="Song P">P Song</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Luan, J" uniqKey="Luan J">J Luan</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Zai, W" uniqKey="Zai W">W Zai</name></author><author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name></author><author><name sortKey="Cao, Z" uniqKey="Cao Z">Z Cao</name></author><author><name sortKey="Ju, D" uniqKey="Ju D">D Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farmer, H" uniqKey="Farmer H">H Farmer</name></author><author><name sortKey="Mccabe, N" uniqKey="Mccabe N">N McCabe</name></author><author><name sortKey="Lord, Cj" uniqKey="Lord C">CJ Lord</name></author><author><name sortKey="Tutt, An" uniqKey="Tutt A">AN Tutt</name></author><author><name sortKey="Johnson, Da" uniqKey="Johnson D">DA Johnson</name></author><author><name sortKey="Richardson, Tb" uniqKey="Richardson T">TB Richardson</name></author><author><name sortKey="Santarosa, M" uniqKey="Santarosa M">M Santarosa</name></author><author><name sortKey="Dillon, Kj" uniqKey="Dillon K">KJ Dillon</name></author><author><name sortKey="Hickson, I" uniqKey="Hickson I">I Hickson</name></author><author><name sortKey="Knights, C" uniqKey="Knights C">C Knights</name></author><author><name sortKey="Martin, Nm" uniqKey="Martin N">NM Martin</name></author><author><name sortKey="Jackson, Sp" uniqKey="Jackson S">SP Jackson</name></author><author><name sortKey="Smith, Gc" uniqKey="Smith G">GC Smith</name></author><author><name sortKey="Ashworth, A" uniqKey="Ashworth A">A Ashworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fenerty, Ke" uniqKey="Fenerty K">KE Fenerty</name></author><author><name sortKey="Padget, M" uniqKey="Padget M">M Padget</name></author><author><name sortKey="Wolfson, B" uniqKey="Wolfson B">B Wolfson</name></author><author><name sortKey="Gameiro, Sr" uniqKey="Gameiro S">SR Gameiro</name></author><author><name sortKey="Su, Z" uniqKey="Su Z">Z Su</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Rabizadeh, S" uniqKey="Rabizadeh S">S Rabizadeh</name></author><author><name sortKey="Soon Shiong, P" uniqKey="Soon Shiong P">P Soon-Shiong</name></author><author><name sortKey="Hodge, Jw" uniqKey="Hodge J">JW Hodge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franzese, E" uniqKey="Franzese E">E Franzese</name></author><author><name sortKey="Centonze, S" uniqKey="Centonze S">S Centonze</name></author><author><name sortKey="Diana, A" uniqKey="Diana A">A Diana</name></author><author><name sortKey="Carlino, F" uniqKey="Carlino F">F Carlino</name></author><author><name sortKey="Guerrera, Lp" uniqKey="Guerrera L">LP Guerrera</name></author><author><name sortKey="Di Napoli, M" uniqKey="Di Napoli M">M Di Napoli</name></author><author><name sortKey="De Vita, F" uniqKey="De Vita F">F De Vita</name></author><author><name sortKey="Pignata, S" uniqKey="Pignata S">S Pignata</name></author><author><name sortKey="Ciardiello, F" uniqKey="Ciardiello F">F Ciardiello</name></author><author><name sortKey="Orditura, M" uniqKey="Orditura M">M Orditura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartley, Gp" uniqKey="Hartley G">GP Hartley</name></author><author><name sortKey="Chow, L" uniqKey="Chow L">L Chow</name></author><author><name sortKey="Ammons, Dt" uniqKey="Ammons D">DT Ammons</name></author><author><name sortKey="Wheat, Wh" uniqKey="Wheat W">WH Wheat</name></author><author><name sortKey="Dow, Sw" uniqKey="Dow S">SW Dow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, C" uniqKey="He C">C He</name></author><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoy, Sm" uniqKey="Hoy S">SM Hoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author><author><name sortKey="Shen, R" uniqKey="Shen R">R Shen</name></author><author><name sortKey="Campbell, A" uniqKey="Campbell A">A Campbell</name></author><author><name sortKey="Mcmichael, E" uniqKey="Mcmichael E">E McMichael</name></author><author><name sortKey="Yu, L" uniqKey="Yu L">L Yu</name></author><author><name sortKey="Ramaswamy, B" uniqKey="Ramaswamy B">B Ramaswamy</name></author><author><name sortKey="London, Ca" uniqKey="London C">CA London</name></author><author><name sortKey="Xu, T" uniqKey="Xu T">T Xu</name></author><author><name sortKey="Carson, We" uniqKey="Carson W">WE Carson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, N" uniqKey="Johnson N">N Johnson</name></author><author><name sortKey="Li, Yc" uniqKey="Li Y">YC Li</name></author><author><name sortKey="Walton, Ze" uniqKey="Walton Z">ZE Walton</name></author><author><name sortKey="Cheng, Ka" uniqKey="Cheng K">KA Cheng</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Rodig, Sj" uniqKey="Rodig S">SJ Rodig</name></author><author><name sortKey="Moreau, La" uniqKey="Moreau L">LA Moreau</name></author><author><name sortKey="Unitt, C" uniqKey="Unitt C">C Unitt</name></author><author><name sortKey="Bronson, Rt" uniqKey="Bronson R">RT Bronson</name></author><author><name sortKey="Thomas, Hd" uniqKey="Thomas H">HD Thomas</name></author><author><name sortKey="Newell, Dr" uniqKey="Newell D">DR Newell</name></author><author><name sortKey="D Ndrea, Ad" uniqKey="D Ndrea A">AD D’Andrea</name></author><author><name sortKey="Curtin, Nj" uniqKey="Curtin N">NJ Curtin</name></author><author><name sortKey="Wong, Kk" uniqKey="Wong K">KK Wong</name></author><author><name sortKey="Shapiro, Gi" uniqKey="Shapiro G">GI Shapiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karantza Wadsworth, V" uniqKey="Karantza Wadsworth V">V Karantza-Wadsworth</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Kravchuk, O" uniqKey="Kravchuk O">O Kravchuk</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Mathew, R" uniqKey="Mathew R">R Mathew</name></author><author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karzai, F" uniqKey="Karzai F">F Karzai</name></author><author><name sortKey="Vanderweele, D" uniqKey="Vanderweele D">D VanderWeele</name></author><author><name sortKey="Madan, Ra" uniqKey="Madan R">RA Madan</name></author><author><name sortKey="Owens, H" uniqKey="Owens H">H Owens</name></author><author><name sortKey="Cordes, Lm" uniqKey="Cordes L">LM Cordes</name></author><author><name sortKey="Hankin, A" uniqKey="Hankin A">A Hankin</name></author><author><name sortKey="Couvillon, A" uniqKey="Couvillon A">A Couvillon</name></author><author><name sortKey="Nichols, E" uniqKey="Nichols E">E Nichols</name></author><author><name sortKey="Bilusic, M" uniqKey="Bilusic M">M Bilusic</name></author><author><name sortKey="Beshiri, Ml" uniqKey="Beshiri M">ML Beshiri</name></author><author><name sortKey="Kelly, K" uniqKey="Kelly K">K Kelly</name></author><author><name sortKey="Krishnasamy, V" uniqKey="Krishnasamy V">V Krishnasamy</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Lee, Mj" uniqKey="Lee M">MJ Lee</name></author><author><name sortKey="Yuno, A" uniqKey="Yuno A">A Yuno</name></author><author><name sortKey="Trepel, Jb" uniqKey="Trepel J">JB Trepel</name></author><author><name sortKey="Merino, Mj" uniqKey="Merino M">MJ Merino</name></author><author><name sortKey="Dittamore, R" uniqKey="Dittamore R">R Dittamore</name></author><author><name sortKey="Marte, J" uniqKey="Marte J">J Marte</name></author><author><name sortKey="Donahue, Rn" uniqKey="Donahue R">RN Donahue</name></author><author><name sortKey="Schlom, J" uniqKey="Schlom J">J Schlom</name></author><author><name sortKey="Killian, Kj" uniqKey="Killian K">KJ Killian</name></author><author><name sortKey="Meltzer, Ps" uniqKey="Meltzer P">PS Meltzer</name></author><author><name sortKey="Steinberg, Sm" uniqKey="Steinberg S">SM Steinberg</name></author><author><name sortKey="Gulley, Jl" uniqKey="Gulley J">JL Gulley</name></author><author><name sortKey="Lee, Jm" uniqKey="Lee J">JM Lee</name></author><author><name sortKey="Dahut, Wl" uniqKey="Dahut W">WL Dahut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lafargue, Cj" uniqKey="Lafargue C">CJ LaFargue</name></author><author><name sortKey="Dal Molin, Gz" uniqKey="Dal Molin G">GZ Dal Molin</name></author><author><name sortKey="Sood, Ak" uniqKey="Sood A">AK Sood</name></author><author><name sortKey="Coleman, Rl" uniqKey="Coleman R">RL Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Ey" uniqKey="Liu E">EY Liu</name></author><author><name sortKey="Xu, N" uniqKey="Xu N">N Xu</name></author><author><name sortKey="O Rey, J" uniqKey="O Rey J">J O’Prey</name></author><author><name sortKey="Lao, Ly" uniqKey="Lao L">LY Lao</name></author><author><name sortKey="Joshi, S" uniqKey="Joshi S">S Joshi</name></author><author><name sortKey="Long, Js" uniqKey="Long J">JS Long</name></author><author><name sortKey="O Rey, M" uniqKey="O Rey M">M O’Prey</name></author><author><name sortKey="Croft, Dr" uniqKey="Croft D">DR Croft</name></author><author><name sortKey="Beaumatin, F" uniqKey="Beaumatin F">F Beaumatin</name></author><author><name sortKey="Baudot, Ad" uniqKey="Baudot A">AD Baudot</name></author><author><name sortKey="Mrschtik, M" uniqKey="Mrschtik M">M Mrschtik</name></author><author><name sortKey="Rosenfeldt, M" uniqKey="Rosenfeldt M">M Rosenfeldt</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Gillespie, Da" uniqKey="Gillespie D">DA Gillespie</name></author><author><name sortKey="Ryan, Km" uniqKey="Ryan K">KM Ryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rouleau, M" uniqKey="Rouleau M">M Rouleau</name></author><author><name sortKey="Patel, A" uniqKey="Patel A">A Patel</name></author><author><name sortKey="Hendzel, Mj" uniqKey="Hendzel M">MJ Hendzel</name></author><author><name sortKey="Kaufmann, Sh" uniqKey="Kaufmann S">SH Kaufmann</name></author><author><name sortKey="Poirier, Gg" uniqKey="Poirier G">GG Poirier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samaniego, R" uniqKey="Samaniego R">R Samaniego</name></author><author><name sortKey="Gutierrez Gonzalez, A" uniqKey="Gutierrez Gonzalez A">A Gutierrez-Gonzalez</name></author><author><name sortKey="Gutierrez Seijo, A" uniqKey="Gutierrez Seijo A">A Gutierrez-Seijo</name></author><author><name sortKey="Sanchez Gregorio, S" uniqKey="Sanchez Gregorio S">S Sanchez-Gregorio</name></author><author><name sortKey="Garcia Gimenez, J" uniqKey="Garcia Gimenez J">J Garcia-Gimenez</name></author><author><name sortKey="Mercader, E" uniqKey="Mercader E">E Mercader</name></author><author><name sortKey="Marquez Rodas, I" uniqKey="Marquez Rodas I">I Marquez-Rodas</name></author><author><name sortKey="Aviles, Ja" uniqKey="Aviles J">JA Aviles</name></author><author><name sortKey="Relloso, M" uniqKey="Relloso M">M Relloso</name></author><author><name sortKey="Sanchez Mateos, P" uniqKey="Sanchez Mateos P">P Sanchez-Mateos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scott, Cl" uniqKey="Scott C">CL Scott</name></author><author><name sortKey="Swisher, Em" uniqKey="Swisher E">EM Swisher</name></author><author><name sortKey="Kaufmann, Sh" uniqKey="Kaufmann S">SH Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, W" uniqKey="Shen W">W Shen</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Fu, X" uniqKey="Fu X">X Fu</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author><author><name sortKey="Luan, J" uniqKey="Luan J">J Luan</name></author><author><name sortKey="Cao, Z" uniqKey="Cao Z">Z Cao</name></author><author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Ju, D" uniqKey="Ju D">D Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shenoy, Gn" uniqKey="Shenoy G">GN Shenoy</name></author><author><name sortKey="Loyall, J" uniqKey="Loyall J">J Loyall</name></author><author><name sortKey="Maguire, O" uniqKey="Maguire O">O Maguire</name></author><author><name sortKey="Iyer, V" uniqKey="Iyer V">V Iyer</name></author><author><name sortKey="Kelleher, Rj" uniqKey="Kelleher R">RJ Kelleher</name></author><author><name sortKey="Minderman, H" uniqKey="Minderman H">H Minderman</name></author><author><name sortKey="Wallace, Pk" uniqKey="Wallace P">PK Wallace</name></author><author><name sortKey="Odunsi, K" uniqKey="Odunsi K">K Odunsi</name></author><author><name sortKey="Balu Iyer, Sv" uniqKey="Balu Iyer S">SV Balu-Iyer</name></author><author><name sortKey="Bankert, Rb" uniqKey="Bankert R">RB Bankert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, C" uniqKey="Sun C">C Sun</name></author><author><name sortKey="Fang, Y" uniqKey="Fang Y">Y Fang</name></author><author><name sortKey="Yin, J" uniqKey="Yin J">J Yin</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Ju, Z" uniqKey="Ju Z">Z Ju</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Vellano, Cp" uniqKey="Vellano C">CP Vellano</name></author><author><name sortKey="Jeong, Kj" uniqKey="Jeong K">KJ Jeong</name></author><author><name sortKey="Ng, Pk" uniqKey="Ng P">PK Ng</name></author><author><name sortKey="Eterovic, Akb" uniqKey="Eterovic A">AKB Eterovic</name></author><author><name sortKey="Bhola, Nh" uniqKey="Bhola N">NH Bhola</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Westin, Sn" uniqKey="Westin S">SN Westin</name></author><author><name sortKey="Grandis, Jr" uniqKey="Grandis J">JR Grandis</name></author><author><name sortKey="Lin, Sy" uniqKey="Lin S">SY Lin</name></author><author><name sortKey="Scott, Kl" uniqKey="Scott K">KL Scott</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Brugge, J" uniqKey="Brugge J">J Brugge</name></author><author><name sortKey="Mills, Gb" uniqKey="Mills G">GB Mills</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Ch" uniqKey="Tang C">CH Tang</name></author><author><name sortKey="Chang, S" uniqKey="Chang S">S Chang</name></author><author><name sortKey="Hashimoto, A" uniqKey="Hashimoto A">A Hashimoto</name></author><author><name sortKey="Chen, Yj" uniqKey="Chen Y">YJ Chen</name></author><author><name sortKey="Kang, Cw" uniqKey="Kang C">CW Kang</name></author><author><name sortKey="Mato, Ar" uniqKey="Mato A">AR Mato</name></author><author><name sortKey="Del Valle, Jr" uniqKey="Del Valle J">JR Del Valle</name></author><author><name sortKey="Gabrilovich, Di" uniqKey="Gabrilovich D">DI Gabrilovich</name></author><author><name sortKey="Hu, Cc" uniqKey="Hu C">CC Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ureshino, H" uniqKey="Ureshino H">H Ureshino</name></author><author><name sortKey="Shindo, T" uniqKey="Shindo T">T Shindo</name></author><author><name sortKey="Kojima, H" uniqKey="Kojima H">H Kojima</name></author><author><name sortKey="Kusunoki, Y" uniqKey="Kusunoki Y">Y Kusunoki</name></author><author><name sortKey="Miyazaki, Y" uniqKey="Miyazaki Y">Y Miyazaki</name></author><author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name></author><author><name sortKey="Saji, H" uniqKey="Saji H">H Saji</name></author><author><name sortKey="Kawaguchi, A" uniqKey="Kawaguchi A">A Kawaguchi</name></author><author><name sortKey="Kimura, S" uniqKey="Kimura S">S Kimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Washington, Mn" uniqKey="Washington M">MN Washington</name></author><author><name sortKey="Suh, G" uniqKey="Suh G">G Suh</name></author><author><name sortKey="Orozco, Af" uniqKey="Orozco A">AF Orozco</name></author><author><name sortKey="Sutton, Mn" uniqKey="Sutton M">MN Sutton</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Mao, W" uniqKey="Mao W">W Mao</name></author><author><name sortKey="Millward, S" uniqKey="Millward S">S Millward</name></author><author><name sortKey="Ornelas, A" uniqKey="Ornelas A">A Ornelas</name></author><author><name sortKey="Atkinson, N" uniqKey="Atkinson N">N Atkinson</name></author><author><name sortKey="Liao, W" uniqKey="Liao W">W Liao</name></author><author><name sortKey="Bast, Rc" uniqKey="Bast R">RC Bast</name></author><author><name sortKey="Lu, Z" uniqKey="Lu Z">Z Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, Zf" uniqKey="Wen Z">ZF Wen</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Huang, F" uniqKey="Huang F">F Huang</name></author><author><name sortKey="Pan, N" uniqKey="Pan N">N Pan</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Fox, Ba" uniqKey="Fox B">BA Fox</name></author><author><name sortKey="Hu, Hm" uniqKey="Hu H">HM Hu</name></author><author><name sortKey="Wang, Lx" uniqKey="Wang L">LX Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Luan, J" uniqKey="Luan J">J Luan</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Song, P" uniqKey="Song P">P Song</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Tian, W" uniqKey="Tian W">W Tian</name></author><author><name sortKey="Ju, D" uniqKey="Ju D">D Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Xian, Z" uniqKey="Xian Z">Z Xian</name></author><author><name sortKey="Luan, J" uniqKey="Luan J">J Luan</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Nan, Y" uniqKey="Nan Y">Y Nan</name></author><author><name sortKey="Luo, M" uniqKey="Luo M">M Luo</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Tian, W" uniqKey="Tian W">W Tian</name></author><author><name sortKey="Ju, D" uniqKey="Ju D">D Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Nan, Y" uniqKey="Nan Y">Y Nan</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Luan, J" uniqKey="Luan J">J Luan</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Tian, W" uniqKey="Tian W">W Tian</name></author><author><name sortKey="Ju, D" uniqKey="Ju D">D Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmer, As" uniqKey="Zimmer A">AS Zimmer</name></author><author><name sortKey="Gillard, M" uniqKey="Gillard M">M Gillard</name></author><author><name sortKey="Lipkowitz, S" uniqKey="Lipkowitz S">S Lipkowitz</name></author><author><name sortKey="Lee, Jm" uniqKey="Lee J">JM Lee</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Feng, Xiaoxia" sort="Feng, Xiaoxia" uniqKey="Feng X" first="Xiaoxia" last="Feng">Xiaoxia Feng</name><name sortKey="Huo, Zhifang" sort="Huo, Zhifang" uniqKey="Huo Z" first="Zhifang" last="Huo">Zhifang Huo</name><name sortKey="Liu, Yuanyuan" sort="Liu, Yuanyuan" uniqKey="Liu Y" first="Yuanyuan" last="Liu">Yuanyuan Liu</name><name sortKey="Song, Hong" sort="Song, Hong" uniqKey="Song H" first="Hong" last="Song">Hong Song</name><name sortKey="Song, Huanqing" sort="Song, Huanqing" uniqKey="Song H" first="Huanqing" last="Song">Huanqing Song</name><name sortKey="Zhou, Chuan" sort="Zhou, Chuan" uniqKey="Zhou C" first="Chuan" last="Zhou">Chuan 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